Promethazine with Codeine Oral Remedy should be used with caution in patients with bone-marrow despair. Leukopenia and agranulocytosis happen to be noted, generally when promethazine has actually been Employed in Affiliation with other acknowledged marrow-harmful agents.

This medicine may possibly make your skin a lot more delicate to sunlight. Use sunscreen if you are outdoors. Avoid sunlamps and tanning beds.

Pregnancy Exams: Diagnostic pregnancy tests depending on immunological reactions among HCG and anti-HCG might cause Fake-adverse or Fake-positive interpretations.

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If a person has overdosed and has severe signs and symptoms for instance passing out or difficulty breathing, connect with 911. Or else, connect with a poison Regulate Heart at once.

It really is soluble in h2o and freely soluble in Alcoholic beverages. The molecular bodyweight is 320.88. Its molecular system is C17H20N2S•HCl, and it has the following chemical construction.

Codeine produces respiratory depression by direct motion on Mind stem respiratory facilities. The respiratory despair requires a reduction from the responsiveness of the Mind stem respiratory facilities to both of those raises in carbon dioxide stress and to electrical stimulation.

Unneeded drugs needs to be disposed of in special ways to make sure that Animals, little ones, and Other individuals can not take in them. Even so, you shouldn't flush this medication down the toilet. Rather, The simplest way to get rid of your medication is thru a drugs acquire-back again application.

It is very a good idea to maintain any products with hydrocodone locked up and away from reach of kids. Even just one dose of hydrocodone may lead to a deadly overdose in youngsters

In the event the individual is bodily depending on opioids, the administration of opioid antagonists may possibly precipitate acute withdrawal syndrome. For that reason, clinicians need to prescribe opioid antagonists cautiously in sufferers with Bodily opioid dependence, and diminished dosages of antagonists really should be deemed for recognized dependent clients.

Any health care details published on this website Promethazine codeine syrup will not be intended as an alternative for educated professional medical guidance and you shouldn't take any action just before consulting using a healthcare professional. See additional info.

Codeine has low plasma protein binding with about 7 to 25% of codeine bound to plasma proteins. Codeine passes the blood Mind barrier and the placental barrier. Small quantities of codeine and its metabolite, morphine, are transferred to human breast milk.

Take this medication by mouth with or with no food items as directed by your health care provider, normally every 4 to 6 several hours as wanted. This medication is often taken with food items if tummy upset takes place. Consume a lot of fluids whenever you use this medication Except usually directed by your doctor.

Significant, existence-threatening, or deadly respiratory melancholy has been described with the usage of opioids, which includes codeine, one of many Lively ingredients in Promethazine with Codeine Oral Alternative. Codeine generates dose-related respiratory melancholy by directly performing over the Mind stem respiratory Centre that controls respiratory rhythm and will create irregular and periodic respiratory. Codeine is topic to variability in metabolism dependent on CYP2D6 genotype, which can cause a heightened exposure for the active metabolite morphine [see WARNINGS AND PRECAUTIONS (five.three)]. Promethazine exerts a depressant effect on the respiratory center which is independent of and additive to that of other respiratory depressants, like codeine [see WARNINGS AND PRECAUTIONS (5.